What's the quickest way to lose a lot of weight? The quickest way to lose weight is to stop eating. But you will gain it back as soon as you start eating again. Sound absurd? Well, any of the other “quickest” ways will have the same result. If you are interested in the best way to lose weight and keep it off, then what you should be asking is, “ what is the correct way?” The correct way is to lose weight is slowly. The same way you gained it. A weight loss goal of 1 to 2 pounds per week is the healthiest way to do it. When you lose weight by adopting a more nutritious diet and increasing your daily activities to include regular exercise your metabolism has time to make the necessary changes to accommodate the change in your weight set point, Basal Metabolism Rate and body composition.